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Catalog# 22,020

Product: MG-132

Description: A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC50 = 3 M). Prevents b-secretase cleavage.

Synonyms: Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal

Molecular Formula: C26H41N3O5

Molecular Weight: 475.6

CAS Number: 133407-82-6.

Appearance: White solid.

Purity: 98% by HPLC.

Storage/Handling: Freeze (-20C)

Shipping: Express Courier


References: Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.; Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. 

For laboratory use only

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Last updated: 06/20/06.