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Geldanamycin, Streptomyces hygroscopicus

Catalog# 16,030

Product: Geldanamycin

Description: A benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells. Rapidly depletes p185c-erbB2 protein tyrosine kinase in breast carcinoma cells. Also known to selectively destabilize mutated p53 protein from a number of breast, leukemia, and prostate cell lines.

Molecular Formula: C29H40N2O9

Molecular Weight: 560.6

CAS Number: 30562-34-6.

Appearance: Off-white solid.

Purity: 95% by HPLC

Storage/Handling: Freeze (-20°C). Protect from light.

Shipping: Express Courier

RTECS: LX8920000

 

References: Vasilevskaya, I.A., and O’Dwyer, P.J. 1999. Cancer Res. 59, 3935.; Mimnaugh, E.G., et al. 1996. J. Biol. Chem. 271, 22796.  

For laboratory use only


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Last updated: 06/20/06.