Geldanamycin, Streptomyces hygroscopicus
Description: A benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells. Rapidly depletes p185c-erbB2 protein tyrosine kinase in breast carcinoma cells. Also known to selectively destabilize mutated p53 protein from a number of breast, leukemia, and prostate cell lines.
Molecular Formula: C29H40N2O9
Molecular Weight: 560.6
CAS Number: 30562-34-6.
Appearance: Off-white solid.
Purity: ≥ 95% by HPLC
Storage/Handling: Freeze (-20°C). Protect from light.
Shipping: Express Courier
References: Vasilevskaya, I.A., and O’Dwyer, P.J. 1999. Cancer Res. 59, 3935.; Mimnaugh, E.G., et al. 1996. J. Biol. Chem. 271, 22796.
For laboratory use only