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Catalog# 10,060

Product: ALLN

Description: Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 M). Inhibits apoptosis in thymocytes and metamyelocytes.

Synonyms: Calpain Inhibitor I; N-Acetyl-Leu-Leu-Nle-CHO

Molecular Formula: C20H37N3O4

Molecular Weight: 383.5

CAS Number: 110044-82-1.

Appearance: White solid.

Purity: 95% by HPLC

Storage/Handling: Refrigerator (+4C)

Shipping: Express Courier


References: Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.; Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.; Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.  

For laboratory use only

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Last updated: 06/20/06.